Innovations in Hypertension and Stroke Research Enhanced by Ultrasound Imaging
- Texas Tech University, School of Veterinarian Medicine
Dr. Prasanth Chelikani’s Lab, Texas Tech University, School of Veterinarian Medicine
Our group is focused on understanding the mechanisms by which signals generated from the gastrointestinal tract, and other peripheral tissues, regulate energy balance and metabolism. Primarily using rodent models to gain insights into the mechanisms by which dietary, pharmacological and surgical interventions promote weight loss and improve metabolic health using a range of physiological and molecular techniques. Knowledge gained from this research is expected to guide the development of more effective strategies for treating obesity and associated complications in humans and pets, as well as enhance feed efficiency of production animals. Current projects are on understanding the mechanisms of weight loss and protection against hypertension and stroke by dietary protein and prebiotic fiber. *All data shown was acquired from Dr. Prasanth Chelikani’s lab using the Prospect T1 High-frequency Ultrasound System
Cardiac Morphology and Functioning
A) Long Axis View
B) Short Axis View
C) Apical Four Chamber View
D) Short Axis M-Mode
E) Mitral Flow
Cardiac Imaging in Mice
These are B-mode imaging of the left ventricle in a mouse A) the parasternal long-axis view, B) the parasternal short-axis view at papillary level, D) the M-mode image showing the movement of the myocardial walls in short-axis view, C) the apical four chamber view, and E) the blood flow velocity of mitral inflow for measuring diastolic cardiac functioning. *From these views, a summary of this analysis will include parameters for both systolic (ejection fraction, fractional shortening, cardiac wall thicknesses, etc.) and diastolic functioning (E:A peak ratio).
Kidney Morphology
Transverse View
A)
B)
C)
D)
Longitudinal View
E)
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G)
H)
Kidney Imaging in Rats
These are B-mode imaging of the left kidney in a rat with A – D highlighting the transverse view A) with the kidney at it’s widest point with B) the landmarks noted, C) the 2D lengths of the kidney, and D) the 2D area measurements of the kidney. E – H are the same, but in the longitudinal view of the kidney. *From these views, a summary of kidney size, shape, and general morphology can be acquired.
Kidney Perfusion
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B)
C)
Kidney Blood Flow Imaging in Rats.
A) Doppler imaging of the left kidney in a rat and B) an image highlighting renal artery blood flow (blue) and renal venous blood flow (red) with C) a pulsed doppler image of renal arterial blood flow velocity. *From these views, a summary of kidney perfusion (pulsatility and resistive indices) can be acquired.
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