The NGB-R is a multimodal, 4D bioprinting platform designed and developed to print live tissues and organs. Combining laser-assisted, micro-valve, and extrusion bioprinting, the NGB-R enables true versatility of bioprinting (from cells to spheroids) and offers the possibility of using a large number of biomaterials and hydrogels. The NGB-R also includes an embedded microscope for in-line cell printing monitoring and relies on a complete software suite for managing bioprinting protocols, from biological CAD to data analysis of manufacturing.
The Next Generation Bioprinting (NGB) systems were designed incorporate high resolution Laser-Assisted Bioprinting into this proprietary and innovative platform.
This research based platform (NGB-R) is modular platform in design, and aims to give tissue engineers and researchers greater freedom in the choice of biomaterials and hydrogels and greater versatility in their research and development programs. The Next Generation Bioprinting (NGB)NGB-R platform from Poietis has been developed to overcome current tissue manufacturing shortfalls and solve critical limitations of existing 3D bioprinting technologies thanks to single-cell resolution and learning-based methods. This platform integrates automation and robotics, and numerous online sensors – including cell microscopy – and Artificial Intelligence processing. In addition, it integrates all bioprinting techniques (laser-assisted bioprinting, bioextrusion and micro-valve bioprinting), a world’s first in the bioprinting market.
Features & Benefits
Bioprinting allows for the fabrication of scaffolds, cells, tissues, and organs with high accuracy, reproducibility and specificity
Multi-Modality, Laser-Assisted, Bio-extrusion, and Micro-valve Bioprinting Techniques
The NGB-R incorporates 3 different bioprinting techniques all in one system:
- Laser-assisted-bioprinting (LAB),
- Bio-extrusion, and
- Micro-valve module
This allows users to continue working with the techniques they have developed and are familiar with, while incorporating new techniques, such as LAB, to further enhance their tissue engineering program
High precision (10µm)
The initial positioning of cells has a huge impact on the evolution of future tissues. While ordinary extrusion- based bioprinting techniques do not allow for precise positioning of printed cells within the hydrogel, NGB-R allows precise positioning of cells at pre-designed pattern
High cellular viability (>95%)
NGB-R’s laser-assisted bioprinting technology is nozzle-free technique with no damage causing
forces occurring in the process. As a result, cell viability
reaches >95% and printed tissues become truly functional
Integrated microscopy and image analysis platform
The NGB-R can come with an optional built-in microscope to acquire images of each individual tissue layer at each step of fabrication.
- 3D image visualization
PIA image analysis platform is developed for 3D reconstruction of the entire tissue as well as in-line 2D & 3D cell patterns analysis. The analysis includes but not limited to automatic and accurate cell counting to ensures all wells have received an equal number of cells, calculating valid droplets percentage according to your preferences, parameters, and desired number of cells per droplet
High resolution, high printing speed
NGB-R is the first commercially available instrument to boast laser-assisted bioprinting, allowing users to deposit micro droplets (ranging in size from 50 μm to 300μm) of cell bioink with a precision of a few microns. With these capabilities all levels of resolution are possible, from aggregates to cellular spots and single cells
Fluidic multi-cell loading module
This features is designed to enable fabrication of larger and more complex tissues in compliance with the Good Manufacturing Practices (GMP).
This optional module includes a Microfluidic cartridge and an automatized pipette or homogenization
NGB-R is designed address automation and reproducibility issues in tissue manufacturing; a. 6-axis robotic arm integrated within NGB-R allows semi- to fully automated fabrication and monitoring workflow
Models & Specifications
Power 220V or 110V
Fully Integrated Biosafety Cabinet
Printing heads included: Laser, as well as bio-extrusion
Printing process: Automated, hands-off with 6-axis Robotic arm
Printing platform: Standard, 6-well & 12-well plates
Computer interface: 21” HD
CAD and HMI software for tissue deign and workflow setup
Multi-modal biofabrication instrument based on a unique high-resolution laser-assisted bioprinting technology. NGB-R is designed and developed for bioprinting living tissues for the purpose of research and discovery.
The same technology is available in clinical version (NGB-C) compatible with Good Manufacturing Practices for production of implantable tissues for clinical use only.
NGB-R Imaging Gallery
Regenerative Medicine - Advanced Therapies
Regenerative medicine is a rapidly growing field that involves replacing or regenerating damaged or diseased cells, tissues or organs to restore normal function.
Bioprinting is a technique that can produce tissues and organs with high degree of complexity and reproducibility. Semi- to fully automated NGB-R bioprinter helps address the current struggles with scale-up manufacturing go tissues of standard quality for in-human use.
Drug Discovery and Therapeutic Testing
3D bioprinted human tissues can bridge the gap in testing of therapeutics from preclinical animal models to in-human trials. In addition, use of bioprinted tissue models allow for high throughput screening of drugs.
3D bioprinting can be used to fabricate in vitro 3D disease modes mimicking the structural and spatial features of the disease environment. This can be used to study the disease mechanism and test therapeutics.
Aesthetic Medicine and Cosmetic Testing
3D bioprinted tissues can replace animal models for testing of cosmetic products., Following the ban on animal testing of beauty product, the market for alternative live tissue models is growing. 3D bioprinted tissue fabricated out of human cells are more ethical and relevant options for validation of aesthetic products.