Niumag QMR06 ECHO-MRI
Versatile ECHO-MRI system for in vivo measuring lean mass, fat mass, and water content
System Overview
The Niumag QMR06 is a quantitative echo-MRI system designed specifically for awake, small laboratory animal body composition measuring. With no prior preparation or anesthetic needed, the QMR06 is effective for user friendly quantitative analysis of lean mass, fat mass, and water content. Echo-MRI quantifies these parameters based on the differences in relaxation times between lean, fat, and water. The QMR06 comes in two models ideal for either mice up to 100g and isolated tissue up to 6g (060H-PRO) or mouse and rat up to 800g and isolated tissue up to 6g (090H-PRO). Permanent magnet technology makes the system low maintenance and easy to operate. The QMR06 is suitable for longitudinal studies due to the non-invasive nature measurement acquisition. Additionally, there is an optional imaging mode available for capturing 2D images of fat distribution.
The QMR06 provides the following measurements:
– Lean mass (g)
– Fat mass (g)
– Water content (g)
Features & Benefits
Zero preparation required
ECHO-MRI is a no hassle method for quantifying body composition with no prior preparation needed such as anesthesia.
Non-invasive
With a non-invasive approach for body composition measurements, the QMR06 is ideal for longitudinal studies.
Awake animal measuring
Without need for anesthetic, you can measure lean mass, fat mass, and water content in awake animals.
Optional imaging mode
The QMR06 has an optional mode to acquire 2D images of the spatial distribution of fat mass.
Permanent magnet technology
With permanent magnet technology operation and maintenance is simplified with the QMR06.
Models & Specifications
| Specification | QMR06-060H-PRO | QMR06-090H-PRO |
|---|---|---|
|
Magnet type |
Permanent magnet (0.15 ±0.015 T) |
Permanent magnet (0.15 ±0.015 T) |
|
Animal Size |
10 – 100g Mouse 0.6 – 6g Tissue |
10 – 800g Mouse / Rat 0.6 – 6g Tissue |
|
Scan Time |
> 3 minutes
|
> 3 minutes |
|
Probe Diameter
|
15mm optional 60mm standard |
15mm optional 60mm standard 90mm standard |
|
Operating System |
Windows 11 |
Windows 11 |
Applications
Metabolic disorders occur when the normal metabolic processes within the body are disrupted, either due to genetic abnormalities, or developed due to environmental conditions.
There is a very long list of metabolic disorders, but most common are diabetes, metabolic syndrome, obesity, etc. There are many small animal models of these diseases which could benefit from ECHO-MRI to help elucidate the genetic, molecular, and biochemical pathways that contribute to these pathologies.
In this study the QMR06 was used to analyze body composition in response to diet induced obesity and the treatment Rutin.
Yuan X, Wei G, You Y, Huang Y, Lee HJ, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W. Rutin ameliorates obesity through brown fat activation. FASEB J. 2017 Jan;31(1):333-345. doi: 10.1096/fj.201600459RR. Epub 2016 Oct 20. PMID: 28049156.
Dietary interventions and research
Drug and therapeutic development studies are key to the progression of target compounds progressing to clinical trials. In addition to efficacy of the target compound on their intended pathology, it is also very important to study their safety and potential toxic effects, some of these effects that may be seen by studying changes in body composition. Small animal studies are routinely used for drug and therapeutic development prior to advancing to clinical trials.
The QMR06 was used in the example below to measure change in body composition in response to different antibiotic treatments.
Li R, Wang H, Shi Q, Wang N, Zhang Z, Xiong C, Liu J, Chen Y, Jiang L, Jiang Q. Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice. PLoS One. 2017 Jul 25;12(7):e0181690. doi: 10.1371/journal.pone.0181690. PMID: 28742883; PMCID: PMC5526540.
Cancer cachexia
Sarcopenia, age related changes in body composition
Publications & Articles
Publication: Enhanced effect of X-rays in the presence of a static magnetic field within a 3D pancreatic cancer model
Publication: Enhanced effect of X- rays in the presence of a static magnetic
Brock University: Muscle & Bone Preservation in Space
Lab Spotlight: Fajardo Laboratory at Brock University Starting with the inaugural manned flight
Unlocking the Key to Muscle & Bone Preservation in Space: The Potential of GSK3 Inhibition
System Used:iNSiGHT DXA Learn More View Paper Here Starting with the inaugural manned