Newton FT-900

Bioluminescence & Fluorescence IN VIS, SWIR (NIR I& NIR-II) for in vivo Imaging

Features

Applications

System Overview

The NEWTON FT-900 is a deeply cooled CCD imager dedicated to SWIR (NIR-I, NIR-II), fluorescence and bioluminescence multi-spectral imaging as it allows for in vivo applications in the visible, near and short-wave infrared spectrum
(VIS/ NIR/ NIR-II). Smart and ultra sensitive, it provides non-ionizing and non-invasive visualization of biological processes in real-time.

This cutting-edge optical imaging system facilitates the penetration of NIR-II
light deeper into small animal tissue with less autofluorescence resulting in
clearer and sharper images.

Bioluminescence & 3D Optical Imaging

Take advantage of the NEWTON FT-900 ultra-high sensitivity provided by its camera and lens (f/0.70). Perform bioluminescence tomography (BLT) to non-invasively visualize and monitor biological processes in small animals, such as mice. Reconstruct the bioluminescent signal into volume through our innovative 3D tomography imaging module which repositions it into the 3D representation of the mouse. Analyze deeper tissue structures with the help of our Mouse Atlas which allows the overlay of the mouse organs to the tomography image. Identify the size and location of the signal much more accurately than with 2D optical imaging. Our CCD and 3D cameras enable ultimate linearity for precise protein quantification over the full dynamic range.

NIR-II Fluorescence

Benefit from a 10 times greater photon penetration depth than visible fluorescence thanks to our strong intensified filtered LED. Witness live and ultra-low noise imaging of biological events with our cooled 1″ CCD SWIR InGaAs camera that boasts 20 micrometer pixels and a video mode, ensuring unrivaled sensitivity and reduced image acquisition times. Visualize multiple reporters simultaneously with our overlay signal feature and choose from 9 excitation channels in the visible RGB and NIR spectrum (440 – 980nm) and 14 high efficiency emission filters, (1000 – 1600nm) all designed with our dual magnetron filter technology that guarantees high signal to noise ratio. The tight LED spectrum is constrained with a narrow excitation filter, to avoid autofluorescence.

VIS Fluorescence

Handle a variety of simultaneous signals for all your applications in the visible light spectrum (440-850nm). Get the benefits of multispectral imaging without worrying about crosstalk. Our unique technology ensures spectral unmixing by using mathematical dye separation so that each channel contains only the signal from one dye. Transport and image even immunocompromised animals by adding our XT 500 isolation chamber (sealed with HEPA-SPF filters) to the system.

Features & Benefits

Metabolic Studies

Study real time metabolism such as drug dispersion, heart rate and breathing thanks to the high frame rate for SWIR II

Luciferase Expression

Use various bioluminescent reporters like firefly luciferase and many fluorescent molecular reagents

Wide Compatibility

Rodents (up to 5 mice and 3 rats, guinea pigs, small rabbits) – Zebra fishes – Organs and tissue sections ex vivo – in vitro samples (in microplates etc…)

All the Applications you Need in One System

Tumor and infection monitoring – Cell migration tracking – Molecules to nanoparticles targeting – Vasculature and microcirculation
visualization – Biodistribution and pharmacokinetics studies

Blood Flow Maps

With our NEWTON FT-900, obtain deep tissue information such as detailed vascular blood flow maps of mice

Applications

Models & Specifications

All Models

Maximum: 20 x 20 cm / Minimum: 6 x 6 cm

All Models

Proprietary V.070
Aperture: f/0.7

All Models

Individually controlled anaesthesia manifolds
Heated animal bed for 5 mice

All Models

License-Free & user friendly
Fully GLP and CFR21-compliant
Data export at 16-bit .tiff or 8-bit .jpg forma

Models	Newton FT 500	Newton FT-900
Bioluminescence	Ultra-high-sensitivity 2D and 3D Optical Tomography	Not applicable
NIR-II Fluorescence: High photon penetration depth (10x greater than visible Fluorescence	VIS camera 400-900 nm InGaAs SWIR camera 900-1700 n Monochrome or color imaging mode From 20 frames per second up to many minutes exposure	nGaAs SWIR camera 900-1700 nm Monochrome or color imaging From 20 frames per second up to many minutes exposure
Emission Filters:	14 High efficiency filters. Peak emission: 500, 550, 600, 650, 700, 750, 800, 850, 1100, 1200, 1300, 1400, 1500, 1600 nm	High efficiency filters. Peak emission: 1100, 1200, 1300, 1400, 1500, 1600 nm
Illumination Sources:	9 Excitations channels: 440, 540, 580, 640, 680, 740, 780, 880, 980 nm	5 Excitations channels: 680, 740, 780, 880, 980 nm