Newton FT-900
Bioluminescence & Fluorescence IN VIS, SWIR (NIR I& NIR-II)
for in vivo Imaging
System Overview
The NEWTON FT-900 is a deeply cooled CCD imager dedicated to SWIR (NIR-I, NIR-II), fluorescence and bioluminescence multi-spectral imaging as it allows for in vivo applications in the visible, near and short-wave infrared spectrum
(VIS/ NIR/ NIR-II). Smart and ultra sensitive, it provides non-ionizing and non-invasive visualization of biological processes in real-time.
This cutting-edge optical imaging system facilitates the penetration of NIR-II
light deeper into small animal tissue with less autofluorescence resulting in
clearer and sharper images.
Bioluminescence & 3D Optical Imaging
Take advantage of the NEWTON FT-900 ultra-high sensitivity provided by its camera and lens (f/0.70). Perform bioluminescence tomography (BLT) to non-invasively visualize and monitor biological processes in small animals, such as mice. Reconstruct the bioluminescent signal into volume through our innovative 3D tomography imaging module which repositions it into the 3D representation of the mouse. Analyze deeper tissue structures with the help of our Mouse Atlas which allows the overlay of the mouse organs to the tomography image. Identify the size and location of the signal much more accurately than with 2D optical imaging. Our CCD and 3D cameras enable ultimate linearity for precise protein quantification over the full dynamic range.
NIR-II Fluorescence
Benefit from a 10 times greater photon penetration depth than visible fluorescence thanks to our strong intensified filtered LED. Witness live and ultra-low noise imaging of biological events with our cooled 1″ CCD SWIR InGaAs camera that boasts 20 micrometer pixels and a video mode, ensuring unrivaled sensitivity and reduced image acquisition times. Visualize multiple reporters simultaneously with our overlay signal feature and choose from 9 excitation channels in the visible RGB and NIR spectrum (440 – 980nm) and 14 high efficiency emission filters, (1000 – 1600nm) all designed with our dual magnetron filter technology that guarantees high signal to noise ratio. The tight LED spectrum is constrained with a narrow excitation filter, to avoid autofluorescence.
VIS Fluorescence
Handle a variety of simultaneous signals for all your applications in the visible light spectrum (440-850nm). Get the benefits of multispectral imaging without worrying about crosstalk. Our unique technology ensures spectral unmixing by using mathematical dye separation so that each channel contains only the signal from one dye. Transport and image even immunocompromised animals by adding our XT 500 isolation chamber (sealed with HEPA-SPF filters) to the system.
Features & Benefits
Metabolic Studies
Study real-time metabolism such as drug dispersion, heart rate and breathing enabled by the high frame rate for SWIR II
Luciferase Expression
Use various bioluminescent reporters like firefly luciferase and many other fluorescent molecular reagents
Wide Compatibility
- Rodents (up to 5 mice and 3 rats, guinea pigs, small rabbits)
- Zebra fish
- Organs and tissue sections ex vivo – in vitro samples (in microplates etc…)
All Applications You Need in One System
- Tumor and infection monitoring
- Cell migration trackingÂ
- Molecules to nanoparticles targeting
- Vasculature and microcirculation
visualization - Biodistribution and pharmacokinetics studies
Blood Flow Maps
Obtain deep tissue information such as detailed vascular blood flow maps
Applications
Tumor & Infection Monitoring
Cell Migration Tracking
Detailed Vascular Blood Flow Maps
Vasculature & Microcirculation Visualization
Biodistribution & Pharmacokinetics Studies
Drug Dispersion
Heart Rate & Breathing
Specifications
- Field of View
All Models
- Maximum: 20 x 20 cm
- Minimum: 6 x 6 cm
- Lens
All Models
- Proprietary Optics: V.070
- Wide lens Aperture: f/0.7
- 3D BLI Tomography
- Animal Care
All Models
- Up to 5 mice capacity
- Heated animal imaging bed
- Individually controlled anaesthesia manifolds
- Acquisition & Analysis Software
All Models
- License-Free & user friendly
- Fully GLP and CFR21-compliant
- Data export at 16-bit .tiff or 8-bit .jpg formats
Publications & Articles
Article Review: E-selectin-targeted polymer-doxorubicin conjugate induces regression of established colorectal liver metastases and improves mice survival: a short article summary.
System Used: Newton 7.0 M-Series View Paper Here In this recent publication,1 published in the acclaimed peer-reviewed journal Nano Today,
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