Intravital Microscopy System

Two-Photon and Confocal Microscopy System for Live Animal Imaging

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Models & Specs

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Features

System Overview

Intravital Microscopy(IVM) is an all-in-one two-photon and/or confocal microscopy system designed and optimized for longitudinal imaging of live animal models in vivo. 

This state-of-art equipment has been designed around ease-of-use and augmented throughput as a next-generation core technology for biologists and translational scientists to elucidate the underlaying mechanism of every biological phenomena at tissue and cellular level. Confocal IVM systems enable optical sectioning of in vivo tissue via rejection of out-of-focus fluorescence light coming from the background tissue which will result in images with high contrast and quality. Two-photon IVM systems are equipped with lasers which use longer-wavelength near-infrared (NIR) fs-pulse excitation capable of deep tissue imaging as well as label-free, non-linear multi-harmonic generation imaging (SHG, THG).

IVM upright systems are equipped with fully-integrate body temperature regulation and anesthesia inlet/outlet into the stage.

The system also includes state-of-the-art live tissue motion compensation for improved image quality, along with ultrafast imaging speeds to track fast-moving imaging targets within the tissue. The system may be configured for confocal or two-photon microscopy modules.

Features & Benefits

Intravital Microscopy(IVM) is an all-in-one two-photon and/or confocal microscopy system designed and optimized for longitudinal imaging of live animal models in vivo.

Integrated heated animal stage and physiological controller

Ensures animal well-being throughout the imaging session, and consistency between animals within a study

Motion compensation function

Provides enhanced image quality on imaging dynamic organs, automatically compensating for the effects of respiratory motions and brain pulses

User-friendly ergonomics and user interface

Allows for ease of use, and reproducible results by experts and non-experts

Integration inhalation anesthesia inlet/outlet

Enables connection to an external inhalation anesthesia machine. Compatible with all universal anesthesia machines.

Animal stabilizing holders and hardware

Quick, secure stabilization of the animal on the stage for time-laps and longitudinal imaging, minimizing motion artefacts

Fast to ultrafast scanning

Allows users to track the movement of several cells in vivo to better understand the biological processes being examined

4-color simultaneous imaging

Multiplexity and simultaneous monitoring of various labelled elements within the tissue

4D Imaging

The software allows for acquisition of 3D stacks of moving objects over time and rendering it as a 4D image

Models & Specifications

IVM-MS3

Compact Two-Photon Laser Unit
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IVM-CMS3

Confocal Laser Unit Compact Two-Photon Laser Unit
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IVM-C3

Confocal Laser Unit
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IVM-M3

Tunable Two-Photon Laser Unit
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IVM-CM3

Confocal Laser Unit Tunable Two-Photon Laser Unit
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Chamber Kits

In vivo imaging window chamber kits for long-term longitudinal imaging of various organs. Optically expose and stabilize organs for intravital imaging. Allows for continuous imaging over several weeks/months post-surgery. Minimizes the need for sacrificing animals after each session and promotes ethical research practices. Dynamic organ window chamber kit used for lung, heart and uterus utilizes micro-suction to stabilize tissue movement.

 

Tissue Motion Stabilizing System (TMS)

  • Staging Platform provide a convenient method for in vivo observation of various organs including liver, intestine, spleen and pancreas
  • Magnetic Base and adjustable height provides flexibility and stability to image the exposed tissue
  • Dynamic organ window chamber Kit used for lung, heart and uterus utilizes micro-suction to stabilize tissue movement
  • Tissue Motion Stabilizer (TMS) helps to maintain negative pressure between tissue and coverslip to prevent tissue movement during imaging.

Models & Specifications

Accessories & Add-ons (All Models)

IVIM Tech Imaging Gallery

Limph Node
Lung
Bone Marrow
Skin
Cancer Xenograft
Cancer Metastasis
Cancer Drug Delivery
Drug Distribution

Past Webinars - IVIM Tech

Publications & Articles

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