Iconeus One
Functional ultrasound platform for high-resolution imaging of brain function and vasculature
System Overview
The Iconeus One is the only full-featured acquisition system for functional ultrasound (fUS) imaging of brain activity. The Iconeus One allows visualization of cerebral blood flow with sub-millimeter spatial resolution and high sensitivity enabling insights into brain activity through neurovascular coupling. The Iconeus One provides a user-friendly platform allowing users without a background in fUS technology to image cerebral blood flow and microvasculature. The system also comes with analysis software that integrates the Allen Mouse Brain Atlas to ensures post-processing is streamlined and a wide-variety of data can be exported. The applications include real time fUS, vascular imaging, functional imaging of neuronal activation (including task-based), functional connectivity mapping, and ultrasound localization microscopy.
Features & Benefits
Plug-and-play functional ultrasound system
- No need for technician to operate the system
- High resolution, sensitivity, and rapid scanning
Ultrasound probes optimized for your application
- Light ultra-high sensitivity probes
- Compatible with awake, moving, resting, and asleep animals
Brain activity and connectivity data without fMRI
- Higher spatial and temporal resolution compared to fMRI
- High sensitivity to detect hemodynamic changes within a single trial
- Animals can be moving or behaving while acquiring
A four-axis motorized scanning platform
- A robotic platform for automated scanning of head-fixed animals
- Four dimensions of movement (X, Y, Z and rotation)
Portable imaging station
- Compact system with wheels
- Designed to fit under the standard lab bench
- Adjustable height for maximum comfort
Easy to use software
- Interactive viewer
- Comprehensive analysis software
- Built-in brain atlas for streamlined analyses
- Additional licenses included for off-line data analysis
Probes
Available Probes: Both 3D and 4D probes are available.
3D probes allow scans in two spatial dimensions (+ time), or three spatial dimensions (+ time, with asynchronous multislicing).
4D probes allow scans in three spatial dimensions + time (simultaneous multislicing or volumetric).
Iconeous One Imaging Gallery
Applications
Applications for:
- Resting-state functional connectivity
- Seed-based correlation mapping
- Connectivity maps of behaving animals
- Drug studies
3D connectivity matrix shows strong interhemispheric connectivity patterns using atlas-based regions in the brain.
- Studies in awake behaving animals
- Studies in head fixed animals
- Sleep studies
- Stimulation studies
- Compatible with other techniques (EEG, LFP, PET, optogenetics)
The cerebral blood volume response to whisker stimulation can be seen in the barrel cortex.
3D visualization of brain vasculature
Treatment studies following stroke
Ultrasound localization microscopy
The vasculature from the front (A) and the back (B) of the rat brain are shown. The hippocampus is isolated in blue (C). Details of cortical arteries and supra collicular network are also shown in D.
Brain activity changes
Functional connectivity changes
Epilepsy studies
ULM maps showing blood velocity (left) and microbubble count (right) of the mouse brain vasculature at a resolution of 6.5 μm. Cortex flow directionality allows discrimination between arterioles and venules.
In plane resolution of about 5 μm
Quantify blood velocities in the mm/s range
Track individual microbubbles as they travel through the blood vessels
ULM maps showing blood velocity (left) and microbubble count (right) of the mouse brain vasculature at a resolution of 6.5 μm. Cortex flow directionality allows discrimination between arterioles and venules.
ULM maps showing blood velocity (left) and microbubble count (right) of the mouse brain vasculature at a resolution of 6.5 μm. Cortex flow directionality allows discrimination between arterioles and venules.
Publications & Articles
Science Corner: Lab Highlight – Max Planck Institute for Biological Cybernetics Tübingen
Utilizing Ultrasound Imaging at Max Planck Institute for Biological Cybernetics Tübingen Dr. Ivan
Science Corner: Utilizing Ultrasound Imaging & Shear Wave Elastography to Evaluate Therapy Response of Tumors at an Early Stage
Utilizing Ultrasound Imaging & Shear Wave Elastography to Evaluate Therapy Response of Tumors
Science Corner: Ultrasound Imaging at Dr. Prasanth Chelikani’s Lab
Innovations in Hypertension and Stroke Research Enhanced by Ultrasound Imaging Dr. Prasanth Chelikani’s