The Paradigm Shift from Normoxia to Physoxia: Enhancing Experimental Precision for Better Translational Outcomes
The overarching aim of this webinar is to facilitate understanding of the role oxygen plays in biological processes. This is fundamental in developing precise experimental models that mimic human biology, and it will help develop improved future translational outcomes. This impacts the core value of investment in medical research and will help attendees position themselves better in the field.
The attendees gained a well understanding on how broadly experimental setup have to factor in different aspects in the cellular environment in order for the produced data to be translational and reproducible.
We went through what/how molecular mechanisms respond to different oxygen levels and what impact this has on a given system. The lecture increased awareness about oxygen’s effects in different fields of biology, be it cancer research, stem cell biology, plant biology, drug discovery, materials science etc.
Specific attention was given on chondrocyte biology and how different oxygen levels affect orthopaedic research.
In addition, attendees gained insight on how oxygen levels can be controlled in an experimental setting from a technical perspective.
About the Speaker (s)
Dr Krista Rantanen has an extensive academic career in the field of cancer research, specifically focusing on oxygen sensing mechanisms. She did her PhD on prolyl hydroxylase function in cancer and subsequently she’s been a part of starting a biomedical engineering company and did her postdoctoral period studying kidney cancer.
In 2018 she joined the Baker Company (USA) as their Director of Scientific Applications and has pursued in this global role since. 2022 she was also invited to be a Visiting Scientist in the research group of Nobel Laureate Sir Peter Ratcliffe at the Francis Crick Institute in London UK. There she continues her research on oxygen sensing mechanisms.
Dr Rantanen is also the lead of the global science for science initiative HypoxEU, the society for oxygen biology research supporting the work of thousands of scientists in the field.