Contrast Agents:
Ultrasound Portfolio
The only contrast agents with single particle sensitivity
Overview
Viscover PolySon L, PolySon H and PolySon T ultrasound agents are unique hard-shell ultrasound microbubbles with ideal physiological and contrast properties for all typical ultrasound methods.
Highly echogenic single particle sensitivity for detailed imaging
PolySon agents are micrometer-sized air-filled polymeric particles, or microbubbles. Comprised of a stabile inert polymeric shell, they exhibit tunable acoustic properties that allow fast and reliable ultrasound. Additionally, PolySon agents provide the added capability of in vivo single bubble quantification via ‘bubble destructive’ methods (stimulated acoustic emission, SAE).
Developed for demanding pre-clinical applications
- PolySon L is a hard-shell ultrasound microbubble agent, optimal for organ perfusion measurements and the visualization of liver and spleen
- PolySon H offers you the same capabilities as PolySon L, but is optimized for measurements at the body surface with high acoustic pressures
- PoySon T is a hard-shell ultrasound microbubble agent that is optimized for imaging of tumors
Discover how you can advance your ultrasound research
This illustrated guide of PolySon products assists you in identifying the optimal contrast agent for your particular application. Read further to reveal how Viscover PolySon can progress your ultrasound research.
Ultrasound Contrast Agent Portfolio
PolySon
PolySon™ L
US agent for perfusion imaging
PolySon L is Viscover´s innovative agent optmized for ultrasound methods at low acoustic pressures and is highly suited for perfusion imaging.
The innovative ultrasound agent, PolySon L:
- Is highly echogenic delivering optimal contrast at all typically used frequencies
- Enables visualization of organ perfusion at microscopic resolutions
Apply PolySon L to:
- Facilitate evaluation of perfusion patterns
- Peform stimulated acoustic emission (SAE) using a low-energy ultrasound beam (low mechanical index)
Physico-chemical properties and structure
Schematic diagram of a PolySon L microbubble
Particle size (number-weighted):
1-3 µm
PolySon™ L cardiac perfusion imaging
Cardiac perfusion in mouse using PolySon L. The three frames from the video clip show the filling of the heart with contrast agent in green false-color.
Order no:
PolySon ™ L ultrasound contrast agent (1 x 5 injections): 130 – 095 – 150
PolySon ™ L ultrasound contrast agent (5 x 5 injections): 130 – 095 – 151
Selected references
- Teupe,C. et al. (2001) Assesment of myocardial perfusion by myocardial contrast echocardiography using harmonic power and the transvenous contrast agent SHU 563A in acute coronary occlusion after reperfusion. Int. J. Cardiol. 77:231-237.
- Hauff, P. et al. (2004) Molecular targeting of lymph nodes with L-selectin ligand-specific US contrast agent: a feasibility study in mice and dogs. Radiology 231: 667-673.
PolySon™ H
Viscover´s innovative ultrasound agent PolySon H consists of highly robust microbubbles, optimized for imaging of the liver at high acoustic pressures. It is perfectly suited for stimulated acoustic emission (SAE) imaging based on inducible bubble rupture using a high-emergy ultrasound beam.
The innovative ultrasound agent, PolySon H:
- Delivers optimal contrast at all typically used frequencies, even above 30 MHz
- Is optimized for imaging of the liver
- Is perfectly suited for stimulated acoustic emission (SAE) using a high-energy ultrasound beam
Apply PolySon H to:
- Effectively visualize liver morphology
- Detect single particles via sensitive partivle acoustic quantification (SPAQ) methods
- Perform stimulated acoustic emission (SAE) using a high-energy ultrasound beam (high mechanical index)
Apply PolySon H to:
- Effectively visualize liver morphology
- Detect single particles via sensitive partivle acoustic quantification (SPAQ) methods
- Perform stimulated acoustic emission (SAE) using a high-energy ultrasound beam (high mechanical index)
Schematic diagram of a PolySon H microbubble
Particle size (number-weighted):
Particle size (number-weighted):
1-3 µm
US agent for liver imaging
Liver imaging based on stimulated acoustic emission using PolySon H. The pseudo-doppler effect resulting from the rupture of single bubbles can be seen in red and blue false-color.
Selected references
- Reinhardt, M. et al. (2005) Sensitive particle acoustic quantification (SPAQ): a new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations. Invest. Radiol. 40: 2-7.
- Tiemann, K. et al. (2000) Stimulated acoustoc emission: pseudo-doppler shifts seen during the destruction of nonmoving microbubbles. Ultrasound Med. Biol. 26: 1161-1167.
- Forsberg, F. et al. (1999) Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 210: 125-132.
Order no:
PolySon ™ H ultrasound contrast agent (1 x 5 injections): 130 – 095 – 152
PolySon ™ H ultrasound contrast agent (5 x 5 injections): 130 – 095 – 153
PolySon™ T
Viscover’s innovative ultrasound agent PolySon T consists of microbubbles, which are optimized for imaging of tumors. The agent’s exceptionally high contrast enhancement coupled with its long blood half-life enables improved visualization of vascularized tumors in animal tumor models.
The innovative ultrasound agent, PolySon T:
- Is highly echogenic delivering optimal contrast at all typically used frequencies
- Has a long circulation time enabling a wide imaging time window
- Is suitable for the visualization of vascularized tumors
Apply PolySon T to:
- Detect tumors in animal tumor models
- Effectively monitor tumor progression
- Evaluate the efficacy of new therapies
Physico-chemical properties and structure
Particle size (number-weighted):
Particle size (number-weighted):
1-3 µm
PolySon™ T tumor imaging
Contrast-enhanced ultrasound (CEUS) image of the left liver lobe of an HBV-transgenic mouse showing hyperenhancement of a hepatocellular carcinoma (HCC) nodule (white arrow) at 6 s post injection of PolySon T.
Selected references
- Marra, P. et al. (2016) SCharacterization of liver nodules with Gd-EOB-DTPA-enhanced MRI and contrast enhanced UltraSound (CEUS) in a transgenic mouse model of hepatocellular carcinoma. European Congress of Radiology, Vienna, Austria, C-1187.
Order no:
PolySon™ T ultrasound contrast agent (1 x 5 injections): 130 – 095 – 148
PolySon™ T ultrasound contrast agent (5 x 5 injections): 130 – 095 – 149
Customized Agents
Customized MRI agents
Imaging agents tailored for your research
The continually expanding Viscover portfolio provides reliable, ready-to-use imaging agents covering a wide spectrum of imaging demands. For those occasions when a customized solution is required, you can rely on the Viscover team for timely assistance.
Examples of our custom offers include:
For MRI:
- Target-specific imaging agents based on both iron oxide and gadolinium-chelate nanoparticles
- Iron oxide nanoparticles of all sizes
- Custom-sized polymeric MRI agents
- Fractionated radiopaque nanoparticles
- Research on target-specific CT imaging agents
- Custom-sized polymeric CT imaging agents
- Target- specific ultrasound microbubbles
- Fractionated ultrasound microbubbles with selected echogenic properties
- NIR dyes, both small molecule and particulate, having various chemical functionalities and optical properties
- Target-specific optical imaging agents
Physico-chemical properties and structure
Schematic diagram of a FeraSpin T nanoparticle
Mean particle size (hydrodynamic diameter):
60 nm
Particle size range:
Narrow size distribution
Relaxivity (37 °C, 1.41 T)
In water:
r1 = 8 L mmol-1 s-1
r2 = 280 L mmol-1 s-1
Viscover’s target-specific agents for all modalities.
Selected References
- Briel, A. et al. (2005) Ultrasound theranostics: antibody-based microbubble conjugates as targeted in vivo contrast agents and advanced drug delivery systems. Modern Biopharmaceuticals. 3: 1301-1324.
- Hauff, P. et al. (2004) Molecular targeting of lymph nodes with L-selectin ligand-specific US contrast agent: a feasibility study in mice and dogs. Radiology 231: 667-673.
- Licha, K. et al. (2001) Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor –targeted fluorescent probes. Bioconjugate Chem. 12: 44-50.
- Zhang, C. et al. (2007) Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer Res. 67: 1555-1562.