Newton FT-900
Bioluminescence & Fluorescence (VIS, NIR-I, and NIR-II/SWIR)
System Overview
The NEWTON FT-900 is the first deeply cooled CCD imager dedicated to both fluorescence and bioluminescence multispectral imaging for a wide range of in-vivo applications. Ideal for preclinical research, it provides non-ionizing and non-invasive visualization of biological processes in real time in the visible, near and short-wave infrared spectrum (VIS/ NIR/ NIR-II). Whether your focus is oncology, immunology, infectious disease, neurology, or biodistribution studies, our all-in-one system accommodates them all.
This cutting-edge optical imaging system achieves 10 times greater photon penetration depth than visible fluorescence, facilitating NIR-II light to travel deeper into small animal tissue with less autofluorescence.
NIR-II Fluorescence
Achieve unmatched depth and sensitivity with imaging technology designed to push past conventional limits. Our intensified filtered LED delivers 10× greater photon penetration depth than visible fluorescence. Capture live, ultra-low-noise events using the cooled 1″CCD SWIR InGaAs camera, equipped with 20 µm pixels and video mode for faster acquisition and superior sensitivity. Visualize multiple reporters with the overlay feature and take advantage of 10 excitation channels (440–980 nm) and 14 high-efficiency emission filters (1000–1500 nm), engineered with dual magnetron filter technology for exceptional signal-to-noise ratios. Narrow excitation filters further minimize autofluorescence, ensuring clarity in every image.
Bioluminescent & 3D Optical Imaging
Reconstruct bioluminescent signals in 3D with our advanced topography imaging module, enabling precise visualization of signal volume. Gain deeper insights into tissue structures using the integrated Mouse Atlas, which overlays organ maps onto the topography image. With Newton’s CCD and 3D cameras, you can accurately pinpoint both the size and location of signals.
VIS Fluorescence
Expand your experimental flexibility by handling a wide range of simultaneous signals across the visible spectrum (440–850 nm). Our advanced spectral unmixing technology eliminates crosstalk, using precise mathematical dye separation to ensure each channel represents a pure signal. For added safety and versatility, transport and image even immunocompromised animals with the XT 500 isolation chamber, fully sealed and equipped with HEPA-SPF filters.
Features & Benefits
Metabolic Studies
Study real-time metabolism such as drug dispersion, heart rate and breathing enabled by the high frame rate for SWIR II
Luciferase Expression
Use various bioluminescent reporters like firefly luciferase and many other fluorescent molecular reagents
Wide Compatibility
- Rodents (up to 10 mice and 3 rats, guinea pigs, small rabbits)
- Zebra fish
- Organs and tissue sections ex vivo – in vitro samples (in microplates etc…)
All Applications You Need in One System
- Tumor and infection monitoring
- Cell migration tracking
- Molecules to nanoparticles targeting
- Vasculature and microcirculation
visualization - Biodistribution and pharmacokinetics studies
Blood Flow Maps
Obtain deep tissue information such as detailed vascular blood flow maps
Applications
Tumor & Infection Monitoring
Cell Migration Tracking
Detailed Vascular Blood Flow Maps
Vasculature & Microcirculation Visualization
Biodistribution & Pharmacokinetics Studies
Drug Dispersion
Heart Rate & Breathing
Specifications
- Field of View
All Models
- Maximum: 20 x 20 cm
- Minimum: 6 x 6 cm
- Lens
All Models
- Proprietary Optics: V.070
- Widest lens aperture on the market (f/0.7)
- 3D BLI Tomography
- Animal Care
All Models
- Up to 10 mouse capacity
- Heated mouse pad (+37°C)
- Individually controlled anesthesia manifolds
- Acquisition & Analysis Software
All Models
License-free and user-friendly
3D BLI topography module
Advanced software for absolute quantification
Fully GLP and CFR21-compliant
Data export at 16-bit .tiff or 8-bit .jpg formats
| Models | Newton FT 900 |
|---|---|
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Imaging Modalities: |
NEWTON FT-900 – Ultimate sensitivity for advanced research with a dual-camera architecture. Designed for scientists seeking exceptional performance and the deepest insights in NIR-II imaging.
– VIS camera 400-900 nm |
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Emission Filters: |
14 high efficiency filters (customizable)
– 8 VIS Narrow-Bandpass filters (30nm) : 500 / 550 / 600 / 650 / 700 / 750 / 800 / 850 nm Equipped with 15 positions motorized filter wheel |
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llumination
Sources: |
– 12 excitation channels: 440 / 480 / 540 / 580 / 640 / 680 / 740 / 780 / 840 / 880 / 940 / 980 nm |
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Cameras: |
Double cameras equipped with proprietary f/0.7 lens
– DarQ-11 Scientific grade 16-bit CCD camera (400-900 nm) |
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Smart Darkroom and Field of View
: |
– Min. 6 x 6 cm ; Max. 20 x 20 cm |
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Animal Handling: |
– Heated Mouse Pad (+20 to 37°C) |
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Acquisition and Analysis Software: |
– Advanced software for absolute quantification |
Publications & Articles
Article: The miR6445-NAC029 module regulates drought tolerance by regulating the expression of glutathione S-transferase U23 and reactive oxygen species scavenging in Populus The miR6445-NAC029 module regulates drought tolerance by regulating the expression of glutathione S-transferase U23 and reactive oxygen species scavenging in Populus
Publication Highlight: The miR6445-NAC029 Module Regulates Drought Tolerance by Regulating the Expression of Glutathione S-Transferase U23 and Reactive Oxygen Species
Immunological Tolerance to Luciferase and Fluorescent Proteins using Tol Mice Enables Development of Improved Tumor Models for Investigating Immunity and Metastasis
Immunological Tolerance to Luciferase and Fluorescent Proteins using Tol Mice Enables Development of Improved Tumor Models for Investigating Immunity and
Frequently Asked Questions – Newton FT-900 Optical Imaging
Frequently Asked Questions: Newton FT-900 Imaging System This frequently asked questions document has been designed to help answer some of