Preclinical CRO Services:
Study execution for biotech, pharmaceutical, and academic research teams.
Multimodal imaging including MRI, PET/CT, optical, ultrasound, DXA, and much more.
Scientific Imaging Expertise
Work with a team experienced in study planning, image acquisition, and quantitative analysis. We support preclinical research in oncology, neuroscience, metabolism, cardiovascular, musculoskeletal, and regenerative medicine. Our focus is reliable data, clean execution, and clear deliverables.
- Study plan and imaging workflow
- Processed datasets and quantitative outputs
- Clear reporting with methods and results
Our Services
Advanced in vivo imaging capabilities, spanning a broad set of modalities:
- Confocal Microscopy Imaging – Optical sectioning with high spatial resolution to clearly resolve cellular and tissue architecture.
- DEXA (Dual-Energy X-ray Absorptiometry) – Quantitative assessment of bone mineral density, body composition, and regional lean and fat mass in small animal models.
- Intravital and Deep Tissue Imaging – Real-time visualization of cellular behavior and interactions within intact, living tissues at depth.
- Live Cell Imaging – Time-resolved microscopy to observe dynamic cellular events as they unfold under physiologically relevant conditions.
- Magnetic Resonance Imaging (MRI) – Detailed anatomical and functional imaging to support cardiac, brain, tumor, and whole-organ investigations.
- In Vivo Optical Imaging – Noninvasive monitoring of molecular and cellular activity using fluorescence or bioluminescence reporters.
- Positron Emission Tomography (PET/CT) – Highly sensitive, quantitative imaging for metabolic profiling and tracer-based studies.
- Short-Wave Infrared (SWIR) Imaging – Improved tissue penetration and contrast for real-time visualization of drug distribution in vivo.
- Single Photon Emission Computed Tomography (SPECT/CT) – Combined functional and anatomical imaging to enable translational and drug development research.
- Super-Resolution Imaging – Imaging at the nanometer scale to reveal ultrastructural details beyond conventional diffraction limits.
- Wide-Field Calcium Imaging – Cortex-wide recording of neuronal activity and functional connectivity using genetically encoded calcium indicators.
Spatial biology workflows integrated with H&E and IHC detection pipelines, including:
- Tissue Microarray (TMA) Construction – End-to-end TMA design and fabrication to support high-throughput, standardized analysis across large tissue collections.
- Fresh and FFPE Single-Cell RNA Sequencing (scRNA-Seq) – High-quality single-cell transcriptomic profiling from fresh and FFPE samples using optimized workflows tailored for FFPE data interpretation.
- Spatial Transcriptomics (Xenium In Situ) – Full-service spatial gene expression analysis enabling single-cell resolution mapping within intact tissue architecture using the Xenium In Situ platform.
Analytical support for drug discovery, contrast agent development, and biomolecular research. With advanced NMR, HPLC, and LC-MS capabilities, we deliver accurate characterization, quantification, and quality control for small molecules, contrast agents, and biologics.
- HPLC Services – Analytical separation and quantification to support small-molecule characterization, impurity detection, stability assessment, and method development.
- LC-MS / Mass Spectrometry – Sensitive mass-based analysis for drug quantification, purity assessment, metabolic profiling, DMPK studies, and compound characterization.
- NMR Spectroscopy (¹H, ¹³C, 2D NMR, and more) – Comprehensive nuclear magnetic resonance analysis for structural elucidation, impurity identification, metabolite confirmation, and verification of compound identity.
- General Staining
- Imaging
- Multiplex IHC and IF
- Opal
- RNAscope
- Scanning
- Sectioning
- Special Stains > 20
- Tissue Processing and Embedding
- Data Structure and Analysis-Ready Outputs: Streamlining downstream analysis and standardizing deliverables.
- Documentation, SOPs, and Reporting Framework: Building protocols, templates, and reporting structure.
- Dosing Strategy and Sampling Schedule: Defining routes, dose levels, and key time points.
- Imaging and Analytical Endpoint Integration: Aligning imaging plans with complementary analytical readouts.
- Model Selection and Cohort Definition: Recommending appropriate in vitro and in vivo models.
- Power and Statistical Planning: Planning for adequate sample size and robust interpretation.
- Randomization, Blinding, and Bias Control: Implementing study controls to reduce bias and improve rigor.
- Study Scoping and Hypothesis Refinement: Clarifying scientific questions and defining endpoints.
Our preclinical CRO services are designed to generate reliable, reproducible datasets that support confident decision making across discovery and translational studies.
