Article Highlight: Intravital Imaging of Cardiac Tissue Utilizing Tissue-Stabilized Heart Window Chamber in Live Animal Model
Ahn, S., Yoon, J.-Y., & Kim, P. (2024).
System Used:
Intravital Microscopy
Overview:
This study introduces a better intravital heart imaging protocol that uses a suction-based cardiac window and AI-driven motion compensation to stabilize the beating mouse heart. Researchers used confocal and two-photon microscopy in live LysM-eGFP mice to clearly see immune cell movement, RBC trafficking, and cardiac muscle structures in real time. The method greatly reduces motion artifacts, allowing for precise measurement of cell dynamics and detailed imaging of sarcomeres and fibrillar organization.
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