Alpha-SPECT Mini (MH3D)
3D SPECT
System Overview
The Alpha-SPECT mini is a high-performance SPECT imaging system for preclinical research (mice and rats). It features high performance CZT sensors providing an unparalleled energy resolution. The scanner offers an ultra-wide stationary FOV to allow for TRU whole-body dynamic scanning of both mice and rats. This allows for imaging up to 4 mice simultaneously. This is a first in its class SPECT scanner with exceptional sensitivity, resolution, and many unique features.
Features & Specifications
Unparalleled energy resolution
E.g., 3-4 keV at 140 keV), ideally suited for multi-isotope imaging
Ultra-high spatial resolution
0.8 mm
Ultra-wide stationary FOV
TRUE whole-body dynamic mouse and rat studies
6 cm x up to 8 cm
Modular design
Choose between CT, Standard Resolution, and High Resolution.
Fully stationary multi-animal
Imaging capability for maximized throughput – 4 mice
User-programmable dual-FOV
Aperture for adaptive whole- /microscopic imaging
Applications
Theranostics
Spectral Imaging
Oncology
Cardiology
Drug Development
Dynamic Development
Metabolic and Bone Diseases
Technical Specifications
| Configuration | A | AA | |
|---|---|---|---|
|
MODE |
Standard Mode |
Focused |
High-Resolution |
|
Field of View
(W x L) |
60mm x 80mm |
40mm x 60mm |
30mm x 60mm |
|
Spatial Resolution @
140keV* |
≤ 2.5 mm |
≤ 1.5 mm |
0.8 mm |
|
Energy Resolution @
140 KeV (FWHM) |
3-4 KeV |
||
|
Sensitivity* |
4200 cps/MBq |
600 cps/MBq |
1700 cps/MBq |
|
Detectors |
CZT (Cadmium Zinc Telluride) |
||
|
Bore Size |
12 cm |
Customizable |
|
|
Animal Handling |
• Comprehensive physiological monitoring |
||
|
Reconstruction
Algorithms |
OSEM |
||
|
* Measured at the full FOV |
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What and Why: Alpha-SPECT Mini™
Case Studies
Targeted Alpha Therapy: Ac-225 @ 80, 100, 117, 218, and 440 keV
Dose: 2µCi, Image time: 60 minutes 4h/24h p.i., Model: Mouse
Alpha Therapy: Ra-223 @ 81-95keV
Dose: 1µCi, Image time:30 – 60 minutes, Model: Non-tumor bearing mouse
High Energy Imaging: Au-198 @ 412 keV
Dose: 3.99MBq, Image time: 2 minutes, Model: Brain tumor mouse
Anatomical Imaging: Tc-99m-MDP
Dose: 120 µCi, Model: bone MDP mouse
Dynamic Imaging – Lu-177
Different cross-sections of a mouse are shown. Images were acquired every minute for 60 minutes.
