Alpha-SPECT Mini (MH3D)
3D SPECT
System Overview
The Alpha-SPECT mini is a high-performance SPECT imaging system for preclinical research (mice and rats). It features high performance CZT sensors providing an unparalleled energy resolution. The scanner offers an ultra-wide stationary FOV to allow for TRU whole-body dynamic scanning of both mice and rats. This allows for imaging up to 4 mice simultaneously. This is a first in its class SPECT scanner with exceptional sensitivity, resolution, and many unique features.
Features & Specifications
Unparalleled energy resolution
E.g., 2.5 keV at 140 keV), ideally suited for multi-isotope imaging
Ultra-high spatial resolution
0.25 mm
Ultra-wide stationary FOV
TRUE whole-body dynamic mouse and rat studies
6 cm x up to 12 cm
Modular design
Customer-selectable imaging configurations:
6 cm x 6 cm, or 6 cm x 9 cm and 6 cm X 12 cm
Fully stationary multi-animal
Imaging capability for maximized throughput – 4 mice
User-programmable dual-FOV
Aperture for adaptive whole- /microscopic imaging
Applications
Theranostics
Spectral Imaging
Oncology
Cardiology
Drug Development
Dynamic Development
Metabolic and Bone Diseases
Technical Specifications
| Truly Stationery FOV | Spatial resolution (mm) | Sensitivity (cps/MBq) | Energy Resolution @140 keV | Bore size | |
|---|---|---|---|---|---|
|
Hi-Res, Mouse |
D 30 mm × L 40 mm |
STD: 0.5 HR: 0.25 |
STD: 2500 (0.25%) HR: 1500 (0.15%) |
STD: 2.5 keV, CZT (UHER: 1.5keV, CdTe) |
12 cm |
|
Large-FOV, Rat |
D 60 mm × L 90 mm
|
1 |
5000 (0.5%) |
2.5 keV |
12 cm |
Phantom Images
Tc-99m IQ phantom images
Preliminary Mouse
Experiment 1: Unbonded Ac-225 in mouse, 1.5 μCi
- Alpha-SPECT-mini with dedicated high-E collimator
- In vivo Imaging of Ac-225 in mouse
- E-window: ~80 keV, (Pb-209, Fr-221, Tl-209, etc.)
- Unbonded Ac-225, 1.5 μCi total
- Imaging time: 30 mins
- Most of the Ac-225 and daughters appears to go to the bone and kidney
Experiment 2: Ac-225-labelled antibody in tumor
- Distribution of Ac-225-labeled antibody in tumor
- Energy window: 5 keV around 218 keV (Fr-221)ey
Experiment 3: Ac-225-labelled antibody in tumor
