System Overview
The ACTIVO bioprinting system features multiple modular printheads optimized for both droplet-based and filament-based bioprinting, enabling precise and controlled deposition of bioinks across a wide viscosity spectrum—from low-viscosity cell-laden solutions to high-viscosity scaffold-forming biomaterials. The system features a patented nebulizing technology that enables additional distinct cross-linking strategies: pH-responsive, enzymatic, and chemical, besides UV LED, and heat-responsive methods.
Features & Benefits
Advanced 3D bioprinting system optimized for low and high-viscosity biomaterials in tissue engineering and regenerative medicine.
3D Stacking of Low-Viscosity Biomaterials
Enables precise layer-by-layer fabrication of delicate structures.
Independent 3D Modeling for Each Layer
Allows for customized designs and complex architectures.
Composite Material Compatibility
Multi-material printing for enhanced biological functionality.
Nebulizing System
Offers pH, enzyme, and chemical (ion) crosslinking methods for optimized biomaterial stabilization.
UV-LED Shutter
Ensures efficient photocuring for rapid and controlled 3D bioprinting.
Cell Printing & Homogenization
Provides solutions for uniform cell distribution and viability.
Cell Printing & Homogenization
Features automatic nozzle-end alignment and build-plate leveling for high-precision printing.
Functions
Low-viscosity Stacking
(Droplet Dispenser + Nebulizer)
3D stacking of low-viscosity biomaterials (Droplet Dispenser + Nebulizer)
The Droplet Dispenser can dispense low-viscosity biomaterials in droplet form, and with the use of a nebulizer, it can form polymer micro-particles (size: 4 um) through neutralization/chemical/enzymatic cross-linking. Additionally, layer-by-layer crosslinking enables easy 3D stacking of low-viscosity materials through gradual curing.
Cell Homogenization
Cell printing and cell homogenization solution
By circulating the fluid mixture, density differences within the solution are prevented, ensuring a uniformity during 3D printing and enabling consistent and high-quality output.
UV-LED Shutter
Ensures efficient photocuring for rapid and controlled 3D bioprinting
Unnecessary curing of materials at the end of the nozzle caused by UV-LED exposure is mitigated by the UV-LED shutter, enabling efficient photopolymerization in 3D printing.
Automatic Calibration
Automated nozzle-end alignment system & build-plate leveling
Surface height of the bioware is automatically measured and calculated, which enables it to fine-tune the X/Y coordinates of the nozzles used in printing for stable extrusion 3D printing.
Applications
Tissue Engineering
Bioprinting Soft and Hard Tissues for Transplantation
Disease Modeling
Replicating Complex Cancer and Disease Environment in a Dish or Organ-on-a-chip Platforms
Organoids
Fabricating Multicellular Organoids i.e Cardiac Organoids
Non-Animal Testing
Alternative Methods of Testing Therapeutics and Cosmetic Substances
Medical Devices
Implantable Devices and Prosthesis
Celluid Bioink
Celluid GM
Celluid AM
Celluid GM + AM
CleCell’s Celluid GM is produced by synthesizing Gelatin, a natural polymer, with Methacrylate, and is available in a freeze-dried sponge form.
Celluid GM is available in two types, providing users with the flexibility to choose based on the viscosity requirements of the intended biological material or tissue for printing.
Celluid AM contains ALMA (Alginate Methacryloyl) and a photoinitiator, allowing the formation of 3D structures upon UV exposure. Users can adjust the concentration for various applications.
Celluid AM is widely used in the research of artificial tissue fabrication and can enhance cell adhesion and cell viability when mixed with GelMA.
The mixture of GelMA and ALMA allows
for higher viscosity output, compared to GelMA bioink alone, due to the high viscosity characteristics of ALMA.
Furthermore, with high cell viability, the GelMA and ALMA combination facilitates the output of optimized structure for human tissue mimicry and cell culture.
News & Webinars
Application Note: Bioprinting Beyond the Limitations of Traditional Cancer Model
M-Series Application Note: Bioprinting Beyond the Limitations of Traditional Cancer...
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(October 2 2024) Webinar: Webinar Agenda: NGBR Bioprinting Systems
(October 2, 2024) Next Generation Bioprinting Platform: A Multimodal Approach...
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Article Review: Single-Cell Bioprinting and Organ-on-Chips: Now a Reality with the NGB-R
System Used: NGB-R M-Series View Paper Here Organs-on-chips (OoCs) are...
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(October 12, 2021) Webinar: Clinical Field MRI As A Measurement Instrument for 3D Printing and Bioprinting
(October 12, 2021) Webinar: Clinical Field MRI As A Measurement...
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