Article: In Vivo Noninvasive Systemic Myography of Acute Systemic Vasoactivity in Female Pregnant Mice

The vasculature is a primary therapeutic target because altered vasoactivity is a key feature of cardiovascular and oncological diseases. While it is ideal for therapies to be selective to diseased vessels, determining this selectivity is challenging. Traditional vessel myography, which examines vascular reactions, is limited to individual artery sections studied ex vivo. Huda, K., Lawrence, D.J., Thompson, W. et al. have developed a technique for in vivo myography using spherical-view photoacoustic tomography.

This enables them to measure real-time vascular responses to vasodilators in pregnant mice, capturing major artery dilation as well as specific vasoactivity in the maternal-fetal vessels. This method provides critical preclinical insights that are not possible with existing methods.